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The latch 2134 defines a ledge or shoulder configured to engage an engagement portion 2322 of the actuator (or push rod) 2320 in the first configuration, as described herein.

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Furthermore, the release member can be configured to release the actuation rod 120 when moved from the first position to the second position.

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Diagnostic tests may involve a panel of variances from one or more genes, often on a solid support, which enables thesimultaneous determination of more than one variance in one or more genes.

The microneedle 5240 has a proximal end portion 5242 and a distal end portion 5244, and defines a lumen 5241.

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In another embodiment, the extraction of the biological sample results in less accumulation of the biological tissue, fluid, or molecule in comparison to the accumulation of the biological tissue, fluid, or molecule in the needle tract that occurs when the biological sample is extracted using a 27 gauge or 30 gauge needle.

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It should be emphasized that it is currently not generally practical to study an entire population to establish the association between a specific disease or condition or response to a treatment and a specific variance or variant form of a gene.

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The delivery device 18000 includes a hub 18270, a puncture member 18240 (also referred to herein as a delivery member or a needle) and an engagement member 18280.

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If variant forms of the gene are useful in explaining interpatientvariation in reponse to the compound in man, then complete absence of the gene in an experimental organism should have a major effect on drug response.

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Currently Phase I trials are performed in unrelated individuals, and there is noconsideration of genetic recruitment criteria, or of genetic analysis of surrogate markers.

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The engagement portion 7322 is configured to be engaged by the user and urge the plunger portion 7324 to slide within the internal volume 7316 defined by the medical injector 7310.

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Said another way, the locking pin 3260 can serve as a safety mechanism to prevent accidental activation of the needle assembly 3200 and prevent advancement of the puncturing member 3260 out of the distal end 3274 of the hub 3270.

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In other preferred embodiments, in cases in which undesirable side-effects may occur or are expected to occur from a particular therapeutic treatment, the selection of a method of treatment can include identifying both afirst and second treatment, where the first treatment is effective to treat the disease or condition, and the second treatment reduces a deleterious effect of the first treatment.

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Conversely, the drug may be given for an indication that it may be used in the treatment of a particular diseaseor condition where the patient has at least one copy of a particular variance, variances, or variant form of a gene.

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Indeed, there has been much written aboutthe potential of pharmacogenetics to change the practice of medicine.

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The results of retrospective genetic analysis of response data in patients treated with the candidate therapy may be the basis for formulating the genetic hypotheses to be tested in theprospective trial.

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