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Subjects with serious intercurrent illness, including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or other nonmalignant medical or psychiatric illness that is uncontrolled or whose control may be jeopardized by the complications of this therapy or may limit compliance with the study requirements (at the discretion of the investigator).

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Vytorin (ezetimibe and simvastatin) is a combination of a selective inhibitor of intestinal cholesterol and related phytosterol absorption, and an HMG-CoA reductase inhibitor (also called a "statin") used to treat high blood cholesterol.

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Effect of ETC-1002 on Serum Low-Density Lipoprotein Cholesterol in Hypercholesterolemic Patients Receiving Statin Therapy.

In addition to taking a cholesterol-lowering medication, making certain changes in your daily habits can also lower your blood cholesterol levels.

Another patient with absent LDL-C receptor function had an LDL-C reduction of 41% with the 80-mg dose.

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